Researchers have developed methods to detect bacteria associated with invasive prostate cancer.
“We used a variety of approaches to detect bacteria, including the complete genetic sequencing of tissue samples, and this method is increasingly being used as we move into the era of genetic medicine,” said Dr. Rachel Hurst of the research team. Principal of UEA and Research at the Norwich Medical School.
“When tumor samples are sorted, the DNA of existing pathogens is also sorted, which makes it possible to detect bacteria,” he said. “We have identified several types of bacteria associated with invasive prostate cancer, some of which are new species that have not yet been discovered.” In total, five types of bacteria are involved, three of which are new.
Two of the three new bacterial species discovered by the team were named after proponents of the study: Porbromonas poppyThe Bob Champion Cancer Trust, and Varicella Prostate Cancer UgiaProstate Cancer UK.
The team found a sequence of bacteria Anaerobes, Peptonifilus, Porphyromonas, Phenolaria And FusobacteriumThese are all anaerobic bacteria, meaning they want to grow without oxygen.
“If one of the specific anaerobic bacteria is detected in a patient’s sample, it is associated with a worsening of prostate cancer and a rapid progression to invasive disease,” Hurst said. “We have also identified possible biological mechanisms that could explain how these bacteria can be linked to cancer.”
Men who detect one or more of those five bacteria in the urine, prostate or tumor tissue are 2.6 times more likely to develop an early stage of prostate cancer than men who have no bacteria at all.
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