about the episode
It has been studied for some time whether psilocybin – the active ingredient in some mushrooms and truffles – could help treat major depression. Previous studies on this were often too small or misleading to really say anything about it, but the results are now from a much larger international study.
In it, they investigated whether a dose of the substance combined with psychological counseling could help people with treatment-resistant depression. Subjects were given 1, 10 or 25 mg, without the practitioner knowing the dose involved. This is to rule out that expectation that guided the process and the outcome.
They saw depression symptoms decrease more in the group with the highest dose. In fact, 30 percent of people in this group had no complaints throughout the three weeks after treatment. These are important findings that should enable the next step of the research – the Phase 3 study.
In this audio you can hear psychiatrist Metten Somers from UMC Utrecht. UMCU was one of three Dutch hospitals that participated in the study. Read more here: Study of how psilocybin works in the New England Journal of Medicine.
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